Order a celiac disease test and check for gluten antibodies

In celiac disease, your immune system may produce specific antibodies in response to gluten. Anti-TTG (tissue transglutaminase antibodies) and endomysium IgA are often used together, because they can complement each other in mapping that immune reaction.

This combination is often used as a first step when celiac disease is suspected, or as a gluten intolerance test when symptoms might be related to gluten.

This celiac disease test may be relevant for men who:

• have digestive complaints such as bloating, diarrhea or abdominal pain after eating gluten-containing foods
• have celiac disease in the family and want to check their antibody levels
• experience unexplained fatigue, nutrient deficiencies or skin issues that could be associated with gluten sensitivity

• Anti-TTG (tissue transglutaminase) (u/ml): antibodies directed against the enzyme tissue transglutaminase. Elevated levels may be associated with celiac disease.
• Endomysium IgA: antibodies targeting the endomysium, a layer of connective tissue. Their presence can support an anti-TTG finding.

Elevated anti-TTG levels, particularly when combined with a positive endomysium IgA, may suggest an autoimmune response to gluten. Antibody levels alone, however, are not enough to confirm celiac disease.

A doctor can determine whether additional evaluation, such as further testing or a specialist referral, is appropriate based on your results. So see your result as a starting point, not a final verdict.

Blood is drawn at a certified sample point. There are 700+ locations across the Netherlands, which you choose yourself after ordering. The appointment usually takes 10 to 15 minutes.

You arrange this without your GP: no referral, just choose a location and time that suit you. The draw is done by trained staff.

This panel may be useful with persistent digestive complaints, unexplained weight loss, chronic fatigue or nutrient deficiencies that could have an autoimmune component. It can also be relevant if a family member has celiac disease.

Because it is a blood test without a referral, you can decide yourself when to begin.

Your result shows each marker alongside a reference range. Positive or elevated values may indicate an immune response to gluten, but do not constitute a diagnosis on their own.

Important: negative values may not be reliable if you have already stopped eating gluten. A doctor can place your result in context and advise on any next steps.

Keep eating gluten-containing foods for at least 6 weeks before the test. Stopping gluten too early can lead to falsely negative results, as antibody levels can fall once gluten is removed from your diet.

Fasting is usually not needed for this test. If in doubt, check with your GP.

Your results are available within a few working days in your personal dashboard, with a reference range and an explanation for each marker. Because celiac disease calls for professional confirmation, it is wise to discuss your result with a doctor, whether it is positive or negative. If you want a broader look at possible nutrient gaps, the vegetarian nutrient panel can be a useful addition.

Every blood test result includes a professional assessment from a BIG-registered doctor. For treatment decisions, discuss your results with your GP.