Celiac Disease

Celiac disease can cause the immune system to produce specific antibodies in response to gluten. Anti-TTG (tissue transglutaminase antibodies) and Endomysium IgA are two markers frequently used in combination because they may provide complementary information about the immune response to gluten.

This test may be relevant for:

• Individuals experiencing digestive symptoms such as bloating, diarrhea, or abdominal discomfort after consuming gluten-containing foods
• Those with a family history of celiac disease who want to check their antibody levels
• Anyone experiencing unexplained fatigue, nutrient deficiencies, or skin issues that could be associated with gluten sensitivity

• Anti-TTG Tissue Transglutaminase (u/ml): antibodies directed against the enzyme tissue transglutaminase. Elevated levels may be associated with celiac disease.
• Endomysium IgA: antibodies targeting the endomysium, a connective tissue layer. The presence of these antibodies can support an Anti-TTG finding.

Elevated Anti-TTG levels, particularly when combined with positive Endomysium IgA, may suggest an autoimmune response to gluten. However, antibody levels alone are not sufficient to confirm celiac disease. A healthcare provider can determine whether additional evaluation, such as further testing or a specialist referral, is appropriate based on the results.

A blood sample is drawn at a certified sample point (afnamepunt). There are over 750 locations across the Netherlands. The procedure typically takes around 10 to 15 minutes. After placing your order, you can select a location and time that works for you.

This panel may be useful when experiencing persistent digestive complaints, unexplained weight loss, chronic fatigue, or nutrient deficiencies that could have an autoimmune component. It can also be relevant for individuals with a family member who has been diagnosed with celiac disease.

Results are presented with reference values for each marker. Positive or elevated results may indicate the presence of an immune response to gluten, but do not constitute a diagnosis on their own. Negative results in someone who has already stopped eating gluten may not be reliable. A healthcare provider can help place the results in context and advise on any next steps.

It is important to continue eating gluten-containing foods for at least 6 weeks before testing. Stopping gluten intake too early may lead to falsely negative results, as antibody levels can decrease when gluten is removed from the diet.

Your results are available in your personal dashboard, presented in a clear report with reference values. Because celiac disease requires professional confirmation, discussing your results with a healthcare provider is recommended, regardless of whether the results are positive or negative.