Tiredness
Investigate some common causes of fatigue: CBC, thyroid, iron, vitamins, glucose, and HbA1c.
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Biomarkers Included
9 biomarkersA panel designed to investigate some common factors that may contribute to fatigue. It combines blood count, thyroid function, iron status, vitamins, and blood sugar markers into a single blood draw focused on energy-related parameters.
Why this test?
Fatigue can have many underlying factors, making it difficult to pinpoint a cause from symptoms alone. This panel targets several systems that are commonly associated with energy levels: thyroid function, iron stores, blood cell production, vitamin status, and glucose metabolism. By measuring them together, the results may help narrow down which areas could be contributing.
Who is this test for?
- Men who experience persistent tiredness that does not improve with adequate sleep and rest
- Those noticing reduced physical or mental performance without an obvious explanation
- Men who want to check whether nutritional deficiencies or metabolic factors may be playing a role in how they feel
- Those who prefer a targeted panel rather than testing individual markers one at a time
What is tested?
- Complete Blood Count (CBC): red blood cells, white blood cells, haemoglobin, haematocrit, and platelets. May reveal anaemia or other haematological factors associated with fatigue.
- Thyroid: TSH (mu/l, ref: 0.27-4.2), Free T3 (pmol/l, ref: 3.1-6.8), Free T4 (pmol/l, ref: 12-22). Thyroid function can influence energy levels, metabolism, and mood.
- Iron: Ferritin (ug/l). Reflects iron stores, which may be depleted before a full blood count shows abnormalities.
- Vitamins: Vitamin B12 (pmol/l, ref: 145-569), Vitamin D 25-OH (nmol/l). Both may be associated with fatigue when levels are low.
- Glucose metabolism: Glucose Fasting (mmol/l), HbA1c (mmol/mol). Blood sugar regulation can affect energy stability throughout the day.
What can this test tell you?
Fatigue is rarely caused by a single factor, which is why this panel casts a wider net. Low Ferritin alongside a normal CBC could suggest early iron depletion before anaemia develops. Thyroid markers outside expected ranges may indicate the thyroid is contributing to low energy. Suboptimal Vitamin D or B12 levels can also be associated with tiredness. And blood sugar irregularities (reflected in Glucose and HbA1c) may affect how consistently energy is available throughout the day. Viewing these results together can help identify patterns that would not be visible from a single test.
How is the sample collected?
A blood sample is drawn at a certified sample point (afnamepunt). There are over 750 locations across the Netherlands. After placing your order, you can select a location and time that works for you. The appointment typically takes around 10 to 15 minutes.
When is this test useful?
This panel may be useful when fatigue is persistent and not easily explained by lifestyle factors such as sleep deprivation or overtraining. It can also be relevant when tiredness is accompanied by other symptoms like difficulty concentrating, muscle weakness, or mood changes, and you want to check whether measurable factors could be involved.
What do the results mean?
Each marker is presented with its reference range. Because fatigue can involve multiple overlapping factors, the most valuable insights often come from looking at the results as a whole. A healthcare provider can help interpret which findings, if any, may be contributing to your symptoms and whether further investigation is appropriate.
Preparation
Fasting for 8 to 12 hours is required for accurate fasting glucose results. Water is permitted during the fasting period.
What happens after the results?
Your results are typically available within a few business days in your personal dashboard. The report includes measured values alongside reference ranges. If the results point toward one or more potential contributing factors, discussing them with a healthcare provider can help determine appropriate next steps.
Frequently Asked Questions
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Choose your blood test
Pick a testosterone check, hormone panel, or prostate screening. Or build a custom test with exactly the markers you want.
Receive your lab referral
Within 2-3 hours you'll receive an email from ZorgDomein with a barcode. Orders outside business hours are processed the next business day.
Get tested at a lab near you
Show the barcode on your phone and bring a valid ID. Done in under 15 minutes.
Receive your report from the doctor
A BIG-registered physician assesses your results and writes a personal report. On your dashboard within a few business days.
Choose your blood test
Pick a testosterone check, hormone panel, or prostate screening. Or build a custom test with exactly the markers you want.
Receive your lab referral
Within 2-3 hours you'll receive an email from ZorgDomein with a barcode. Orders outside business hours are processed the next business day.
Get tested at a lab near you
Show the barcode on your phone and bring a valid ID. Done in under 15 minutes.
Receive your report from the doctor
A BIG-registered physician assesses your results and writes a personal report. On your dashboard within a few business days.
Always a location near you
With more than 450+ certified phlebotomy points across the Netherlands.
What We Test
This panel includes 9 biomarkers, each tested at a certified laboratory using medical-grade equipment.
HbA1c (glycated haemoglobin) reflects your average blood sugar levels over the past 2-3 months. It is the gold standard for long-term blood sugar monitoring and diabetes management.
Learn moreTSH, or thyroid-stimulating hormone, is produced by the pituitary gland and controls the thyroid. It is the most commonly used blood value to assess thyroid function. An abnormal TSH level can indicate an underactive thyroid (hypothyroidism) or an overactive thyroid (hyperthyroidism). Thyroid problems are common — especially in women — and can cause a wide range of symptoms, from fatigue and weight gain to palpitations and nervousness.
Learn moreGlucose is the primary energy source for your body. Your fasting glucose level (measured after at least eight hours of fasting) indicates how well your body can regulate blood sugar. An elevated fasting glucose can indicate prediabetes or type 2 diabetes, while a low value (hypoglycaemia) can cause symptoms such as trembling, sweating, and difficulty concentrating.
Learn moreFree T4 (thyroxine) is the main hormone produced by the thyroid gland. It may serve as a precursor that your body converts into the more active T3. Healthcare providers often consider Free T4 a primary indicator of thyroid gland output.
Learn moreVitamin B12 is considered essential for red blood cell formation, neurological function, and DNA synthesis. Deficiency may develop gradually and is sometimes associated with dietary patterns. Healthcare providers can help interpret your results.
Learn moreVitamin D is a fat-soluble vitamin that plays a key role in calcium absorption, bone health, and immune function. It is primarily produced in the skin through sunlight exposure and can also be obtained from certain foods and supplements.
Learn moreFree T3 (triiodothronine) is considered the most active thyroid hormone. It may play a key role in regulating metabolism, energy production, and body temperature. Healthcare providers often assess Free T3 alongside other thyroid markers for a comprehensive picture.
Learn moreFerritin is the primary storage protein for iron in your body. It reflects your iron stores more accurately than iron levels themselves, which can fluctuate considerably throughout the day. Low ferritin is the earliest sign of iron deficiency — often measurable before your haemoglobin drops and anaemia develops. High ferritin can indicate iron overload but is also a widely used inflammation marker. Interpretation always depends on the clinical context.
Learn moreA complete blood count (CBC) is a comprehensive blood test that evaluates the major components of your blood: red blood cells, white blood cells, and platelets. It is one of the most commonly ordered blood tests and provides a broad overview of your overall health.
Learn moreHbA1c (Glycated Hemoglobin)
MetabolicHbA1c (glycated haemoglobin) reflects your average blood sugar levels over the past 2-3 months. It is the gold standard for long-term blood sugar monitoring and diabetes management.
HbA1c provides a long-term view of blood sugar control, unlike fasting glucose which reflects a single point in time. It is essential for diabetes diagnosis and management. Consult your healthcare provider.
TSH (Thyroid Stimulating Hormone)
ThyroidTSH, or thyroid-stimulating hormone, is produced by the pituitary gland and controls the thyroid. It is the most commonly used blood value to assess thyroid function. An abnormal TSH level can indicate an underactive thyroid (hypothyroidism) or an overactive thyroid (hyperthyroidism). Thyroid problems are common — especially in women — and can cause a wide range of symptoms, from fatigue and weight gain to palpitations and nervousness.
TSH is often used as a first test to see how the thyroid is functioning. A value within the normal range is generally considered reassuring, while a high-normal or unusual value may be a reason to look further. An underactive thyroid, for example, can go together with a higher TSH. Your GP can place your TSH result in context and decide with you whether further testing is needed. In some cases the GP refers to an internist-endocrinologist. Sometimes it is enough to check less often.
Glucose (Fasting)
MetabolicGlucose is the primary energy source for your body. Your fasting glucose level (measured after at least eight hours of fasting) indicates how well your body can regulate blood sugar. An elevated fasting glucose can indicate prediabetes or type 2 diabetes, while a low value (hypoglycaemia) can cause symptoms such as trembling, sweating, and difficulty concentrating.
Type 2 diabetes affects more than one million people in the Netherlands, and an estimated 1.1 million more have prediabetes without knowing it. Untreated, diabetes significantly increases the risk of cardiovascular disease, kidney damage, eye problems, and nerve damage. Prediabetes is a reversible stage. With lifestyle adjustments — weight loss, more exercise, less sugar and processed carbohydrates — more than half of people with prediabetes can prevent developing diabetes. This makes early detection through a fasting glucose test or HbA1c very valuable.
Free T4 (Thyroxine)
ThyroidFree T4 (thyroxine) is the main hormone produced by the thyroid gland. It may serve as a precursor that your body converts into the more active T3. Healthcare providers often consider Free T4 a primary indicator of thyroid gland output.
Free T4 may help your healthcare provider determine whether your thyroid gland is producing adequate hormone levels. Some experts consider it one of the most informative markers for detecting both overactive and underactive thyroid conditions early.
Vitamin B12
VitaminsVitamin B12 is considered essential for red blood cell formation, neurological function, and DNA synthesis. Deficiency may develop gradually and is sometimes associated with dietary patterns. Healthcare providers can help interpret your results.
Vitamin B12 is believed to be vital for healthy nerve cells, red blood cell formation, and DNA synthesis. A vitamin B12 deficiency can develop slowly and is sometimes associated with anaemia, fatigue, and tingling in your hands and feet. Having a blood test done can help bring a vitamin shortage into view, so you can discuss it with your GP.
Vitamin D (25-OH)
VitaminsVitamin D is a fat-soluble vitamin that plays a key role in calcium absorption, bone health, and immune function. It is primarily produced in the skin through sunlight exposure and can also be obtained from certain foods and supplements.
Adequate vitamin D levels are essential for strong bones, a well-functioning immune system, and overall well-being. Low levels may be associated with an increased risk of bone disorders, mood changes, and weakened immunity. Consult your healthcare provider for personalised advice.
Free T3 (Triiodothyronine)
ThyroidFree T3 (triiodothronine) is considered the most active thyroid hormone. It may play a key role in regulating metabolism, energy production, and body temperature. Healthcare providers often assess Free T3 alongside other thyroid markers for a comprehensive picture.
Free T3 may help your healthcare provider evaluate how well your thyroid is functioning at a cellular level. Some experts suggest it can reveal conversion issues that other thyroid tests might miss, potentially offering a more complete understanding of thyroid health.
Ferritin
MineralsFerritin is the primary storage protein for iron in your body. It reflects your iron stores more accurately than iron levels themselves, which can fluctuate considerably throughout the day. Low ferritin is the earliest sign of iron deficiency — often measurable before your haemoglobin drops and anaemia develops. High ferritin can indicate iron overload but is also a widely used inflammation marker. Interpretation always depends on the clinical context.
Iron is important for oxygen transport, energy and your immune system. A ferritin test can help bring iron deficiency into view before anaemia develops, or iron overload that may strain organs over time. Reference values differ per laboratory and per person; in adults they often lie somewhere between 25 and 250 micrograms per litre, and for some groups between 20 and 100. If values are abnormal, your GP may suggest further investigations. The value is usually not viewed on its own. Your GP often also looks at <a href="/en/biomarkers/iron-serum">iron</a>, <a href="/en/biomarkers/hemoglobin">haemoglobin</a> and <a href="/en/biomarkers/transferrin">transferrin</a> to get a fuller picture. Consult your GP for personalised advice.
Complete Blood Count (CBC)
HematologyA complete blood count (CBC) is a comprehensive blood test that evaluates the major components of your blood: red blood cells, white blood cells, and platelets. It is one of the most commonly ordered blood tests and provides a broad overview of your overall health.
The CBC is a cornerstone of preventive healthcare and diagnostic medicine. It can help detect a wide range of conditions including anemia, infections, immune disorders, blood cancers, and clotting problems. Regular CBC testing supports early detection and ongoing health monitoring.
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