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Hormones

IGF-BP3

IGF-BP3 is the primary carrier protein for IGF-1 and plays a role in regulating growth factor activity. For men, understanding IGF-BP3 levels alongside IGF-1 can help assess muscle maintenance, recovery potential, and overall vitality.

Doctor's Assessment Included

Reference Ranges

No established reference range

There is no international reference preparation for IGF-BP3, so assays differ by roughly 24% and reference values are not transferable between laboratories. The Netherlands has no national reference interval and no external quality control for it, and the LUMC declines to publish a table. The value is also strongly age- and sex-dependent.

Unit: nmol/l

Reference ranges may vary between laboratories. When you order a test, a BIG-registered doctor assesses your personal results in context. For treatment decisions, discuss your results with your GP.

What It Measures

This test measures the concentration of IGF-BP3 in your blood. IGF-BP3 is the most abundant IGF binding protein and regulates the availability and activity of IGF-1 by transporting it through the bloodstream and controlling its release to tissues.

Why It Matters

For men focused on strength and body composition, IGF-BP3 helps regulate how IGF-1 is delivered to muscles and tissues. Monitoring both markers together may provide deeper insight into anabolic capacity and recovery.

When to Test

Testing may be recommended alongside IGF-1 when evaluating suspected growth hormone disorders, monitoring pituitary function, or assessing nutritional status. Your healthcare provider can advise on appropriate timing.

Symptoms

Low Levels

Some people with low IGF-BP3 may experience symptoms similar to growth hormone deficiency, such as fatigue, reduced muscle mass, or poor recovery. Low levels may also be associated with liver or nutritional issues.

High Levels

Elevated IGF-BP3 levels are less commonly associated with specific symptoms but may indicate excessive growth hormone production or other conditions. Consult your healthcare provider for interpretation of results.

Lifestyle Tips

Maintaining balanced nutrition, adequate protein intake, and regular physical activity may support healthy IGF-BP3 levels. Good sleep hygiene is also important, as growth hormone is primarily released during deep sleep.

Frequently Asked Questions

Why is IGF-BP3 tested alongside IGF-1?
IGF-BP3 carries most of the IGF-1 in your blood. Testing both together gives a more complete view of growth hormone activity and helps your healthcare provider interpret results more accurately.
What can cause low IGF-BP3 levels?
Low levels may be associated with growth hormone deficiency, liver disease, malnutrition, or certain chronic conditions. Your healthcare provider can determine the underlying cause.
Can I improve my IGF-BP3 levels naturally?
Balanced nutrition, regular exercise, and adequate sleep may support healthy IGF-BP3 production. Consult your healthcare provider for personalized recommendations.

Tests with related values

These panels measure values from the same category as this marker.

Health Checkups

Men Over 40 Panel

Age-appropriate screening including testosterone and PSA.

HbA1c (Glycated Hemoglobin) PSA (Prostate-Specific Antigen) ALT (Alanine Aminotransferase) TSH (Thyroid Stimulating Hormone) Triglycerides Creatinine Free T4 (Thyroxine) LDL Cholesterol SHBG (Sex Hormone Binding Globulin) Total Cholesterol Vitamin D (25-OH) Free Testosterone Total Testosterone hs-CRP (High Sensitivity CRP) HDL Cholesterol
€279,-
Health Checkups

Complete Men's Health Panel

A broad men's health panel: hormones, heart, metabolic, and organ function in one blood draw.

HbA1c (Glycated Hemoglobin) ALT (Alanine Aminotransferase) TSH (Thyroid Stimulating Hormone) Triglycerides Creatinine Glucose (Fasting) Free T4 (Thyroxine) LDL Cholesterol SHBG (Sex Hormone Binding Globulin) Total Cholesterol Vitamin D (25-OH) Free Testosterone Total Testosterone Ferritin hs-CRP (High Sensitivity CRP) HDL Cholesterol
€289,-

IGF-BP3

€59,-