Kidney Function
Creatinine, eGFR, and BUN: key kidney markers.
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Biomarkers Included
3 biomarkersThis test measures three markers that reflect kidney function: creatinine, eGFR, and urea (BUN). Together, they can provide a snapshot of how well your kidneys are filtering waste products from your blood.
Why this test?
Your kidneys filter waste, regulate fluid balance, and help maintain blood pressure. Changes in kidney function often develop silently, without noticeable symptoms in the early stages. This panel measures creatinine, eGFR, and urea to give you direct data on your kidney performance.
Who is this test for?
This test may be relevant for:
- Men who follow a high-protein diet and want to check their kidney markers
- Those with a family history of kidney-related conditions
- Men using supplements such as creatine who want to monitor kidney function
- Anyone who wants baseline data on kidney health
What is tested?
- Creatinine (umol/l): a waste product from muscle metabolism; the kidneys normally filter it out efficiently
- eGFR (ml/min): an estimated glomerular filtration rate that indicates how well the kidneys are filtering blood
- Urea (BUN) (mmol/l): a byproduct of protein metabolism; elevated levels may suggest the kidneys are not clearing waste as effectively
What can this test tell you?
Creatinine and eGFR work together: elevated creatinine with a lower eGFR may suggest reduced kidney filtration capacity. Urea adds another layer of information, as it reflects both kidney function and protein intake. By evaluating all three markers, you get a more reliable picture than any single value could provide. Deviations may have various causes and do not automatically indicate a problem.
How is the sample collected?
A blood sample is drawn at a certified sample point (afnamepunt). There are over 750 locations throughout the Netherlands. The procedure takes approximately 10 to 15 minutes.
When is this test useful?
This test may be useful if you follow a high-protein diet, use creatine supplements, have a family history of kidney issues, or simply want to establish baseline values. It can also be relevant if you experience symptoms like changes in urination patterns, unexplained swelling, or persistent fatigue.
What do the results mean?
Your results will show whether each marker falls within the reference range. An elevated creatinine or urea, or a lower-than-expected eGFR, may warrant further investigation. However, factors such as muscle mass, hydration, and diet can influence these values. A healthcare provider can help you interpret the results in the context of your personal health profile.
What happens after the results?
Your results are typically available within a few business days. You will receive a clear report showing each marker and its reference range. Consider reviewing your results with a healthcare provider who can provide personalized context and guidance.
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Choose your blood test
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Receive your lab referral
Within 2-3 hours you'll receive an email from ZorgDomein with a barcode. Orders outside business hours are processed the next business day.
Get tested at a lab near you
Show the barcode on your phone and bring a valid ID. Done in under 15 minutes.
Receive your report from the doctor
A BIG-registered physician assesses your results and writes a personal report. On your dashboard within a few business days.
Choose your blood test
Pick a testosterone check, hormone panel, or prostate screening. Or build a custom test with exactly the markers you want.
Receive your lab referral
Within 2-3 hours you'll receive an email from ZorgDomein with a barcode. Orders outside business hours are processed the next business day.
Get tested at a lab near you
Show the barcode on your phone and bring a valid ID. Done in under 15 minutes.
Receive your report from the doctor
A BIG-registered physician assesses your results and writes a personal report. On your dashboard within a few business days.
Always a location near you
With more than 450+ certified phlebotomy points across the Netherlands.
What We Test
This panel includes 3 biomarkers, each tested at a certified laboratory using medical-grade equipment.
BUN (blood urea nitrogen) measures the amount of urea nitrogen in your blood, a waste product formed when the body breaks down protein. It is primarily used to evaluate kidney function and can be influenced by diet, hydration status, and liver health.
Learn moreCreatinine is a waste product of creatine, a substance your muscles use for energy supply. The kidneys filter creatinine from your blood and excrete it through urine. When the kidneys function less well, creatinine accumulates in the blood. The creatinine level is therefore one of the most important markers for assessing kidney function. It is often measured alongside eGFR, which gives a more precise estimate of how well your kidneys are working.
Learn moreThe eGFR (estimated glomerular filtration rate) estimates how much blood your kidneys filter per minute. It is calculated from your creatinine level, age, sex, and ethnicity using the CKD-EPI formula. eGFR is more accurate than creatinine alone and is used to classify kidney function loss into stages. An eGFR above 90 ml/min is normal; below 60 ml/min indicates clinically relevant kidney function reduction.
Learn moreUrea (BUN)
KidneyBUN (blood urea nitrogen) measures the amount of urea nitrogen in your blood, a waste product formed when the body breaks down protein. It is primarily used to evaluate kidney function and can be influenced by diet, hydration status, and liver health.
BUN is a valuable marker for assessing how effectively your kidneys are filtering waste from your blood. Elevated levels may indicate that the kidneys are not functioning optimally, which can be associated with dehydration, kidney disease, or other underlying conditions. Monitoring BUN alongside other kidney markers such as creatinine and eGFR provides a more comprehensive picture of renal health and helps detect potential problems early.
Creatinine
KidneyCreatinine is a waste product of creatine, a substance your muscles use for energy supply. The kidneys filter creatinine from your blood and excrete it through urine. When the kidneys function less well, creatinine accumulates in the blood. The creatinine level is therefore one of the most important markers for assessing kidney function. It is often measured alongside eGFR, which gives a more precise estimate of how well your kidneys are working.
Chronic kidney damage often progresses silently and rarely causes symptoms in early stages. Your kidneys can lose up to 50% of their function before you notice anything. Creatinine and eGFR are the standard markers for early detection. In diabetes and high blood pressure — the two leading causes of chronic kidney damage — periodic creatinine monitoring is part of clinical guidelines. Kidney function monitoring is also recommended during long-term use of NSAIDs (painkillers such as ibuprofen and diclofenac), ACE inhibitors, or certain antibiotics. An elevated creatinine does not always indicate kidney damage. In people with high muscle mass (strength athletes) or high protein intake, the value can naturally be higher. Conversely, low creatinine in the elderly or in people with little muscle mass can mask reduced kidney function — eGFR is more reliable in those cases.
eGFR (Estimated Glomerular Filtration Rate)
KidneyThe eGFR (estimated glomerular filtration rate) estimates how much blood your kidneys filter per minute. It is calculated from your creatinine level, age, sex, and ethnicity using the CKD-EPI formula. eGFR is more accurate than creatinine alone and is used to classify kidney function loss into stages. An eGFR above 90 ml/min is normal; below 60 ml/min indicates clinically relevant kidney function reduction.
Chronic kidney damage is largely irreversible, but progression can be slowed or stopped if detected early. eGFR is the cornerstone of that early detection. Diabetes and high blood pressure together account for more than 60% of all cases of chronic kidney damage — periodic eGFR monitoring in these patient groups is therefore essential. At an eGFR below 60 ml/min, medication adjustments are often needed because many drugs are excreted by the kidneys. The dosage of contrast agents for CT scans must also be adjusted.
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