Graves Disease
TSH, Free T4, Free T3, and TSH Receptor Antibodies to help assess Graves' disease.
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Biomarkers Included
4 biomarkersA thyroid panel combining TSH, Free T4, Free T3, and TSH Receptor Antibodies. These markers together may help assess whether thyroid overactivity could be related to Graves' disease.
Why this test?
Graves' disease is an autoimmune condition that can cause the thyroid to produce excess hormones. Standard thyroid panels measure TSH and thyroid hormones, but adding TSH Receptor Antibodies may help distinguish Graves' disease from other causes of thyroid overactivity.
Who is this test for?
This test may be relevant for:
- Individuals who have been told their thyroid values are elevated and want further insight
- Those experiencing symptoms that could be associated with an overactive thyroid, such as unexplained weight changes, restlessness, or heat sensitivity
- Anyone who wants to check for the presence of TSH Receptor Antibodies alongside standard thyroid markers
What is tested?
- TSH (mu/l, ref: 0.27-4.2): thyroid-stimulating hormone, produced by the pituitary gland to regulate thyroid activity.
- Free T4 (pmol/l, ref: 12-22): the unbound, active form of thyroxine.
- Free T3 (pmol/l, ref: 3.1-6.8): the unbound, active form of triiodothyronine, the more potent thyroid hormone.
- TSH Receptor Antibodies (kU/l): antibodies that may stimulate the TSH receptor, potentially causing the thyroid to overproduce hormones.
What can this test tell you?
The combination of suppressed TSH with elevated Free T4 or Free T3 may suggest thyroid overactivity. If TSH Receptor Antibodies are also present, this pattern could point toward Graves' disease as the underlying cause. However, these results should always be interpreted by a healthcare provider, as multiple conditions can produce similar patterns.
How is the sample collected?
A blood sample is drawn at a certified sample point (afnamepunt). There are over 750 locations across the Netherlands. The procedure typically takes around 10 to 15 minutes. After placing your order, you can select a location and time that works for you.
When is this test useful?
This panel may be useful when experiencing symptoms that could be associated with thyroid overactivity, such as unexplained weight loss, increased heart rate, tremors, or anxiety. It can also be relevant for individuals who have previously had abnormal thyroid results and want a more targeted follow-up.
What do the results mean?
Results are presented with reference ranges for each marker. The presence or absence of TSH Receptor Antibodies, combined with the thyroid hormone levels, can provide additional context. A healthcare provider can help determine what the overall pattern may indicate and whether further evaluation is appropriate.
What happens after the results?
Your results are available in your personal dashboard, presented in a clear report with reference ranges. Because Graves' disease requires professional assessment, discussing your results with a healthcare provider is recommended, particularly if antibodies are detected or thyroid values fall outside the reference range.
From order to report in 4 steps
No referral needed. No waiting list. Just order and go.
Choose your blood test
Pick a testosterone check, hormone panel, or prostate screening. Or build a custom test with exactly the markers you want.
Receive your lab referral
Within 2-3 hours you'll receive an email from ZorgDomein with a barcode. Orders outside business hours are processed the next business day.
Get tested at a lab near you
Show the barcode on your phone and bring a valid ID. Done in under 15 minutes.
Receive your report from the doctor
A BIG-registered physician assesses your results and writes a personal report. On your dashboard within a few business days.
Choose your blood test
Pick a testosterone check, hormone panel, or prostate screening. Or build a custom test with exactly the markers you want.
Receive your lab referral
Within 2-3 hours you'll receive an email from ZorgDomein with a barcode. Orders outside business hours are processed the next business day.
Get tested at a lab near you
Show the barcode on your phone and bring a valid ID. Done in under 15 minutes.
Receive your report from the doctor
A BIG-registered physician assesses your results and writes a personal report. On your dashboard within a few business days.
Always a location near you
With more than 450+ certified phlebotomy points across the Netherlands.
What We Test
This panel includes 4 biomarkers, each tested at a certified laboratory using medical-grade equipment.
TSH, or thyroid-stimulating hormone, is produced by the pituitary gland and controls the thyroid. It is the most commonly used blood value to assess thyroid function. An abnormal TSH level can indicate an underactive thyroid (hypothyroidism) or an overactive thyroid (hyperthyroidism). Thyroid problems are common — especially in women — and can cause a wide range of symptoms, from fatigue and weight gain to palpitations and nervousness.
Learn moreTSH receptor antibodies (TRAb) target the TSH receptor on thyroid cells. These antibodies are primarily associated with Graves' disease and may either stimulate or block thyroid function. Your healthcare provider can help interpret what your TRAb results mean for your thyroid health.
Learn moreFree T4 (thyroxine) is the main hormone produced by the thyroid gland. It may serve as a precursor that your body converts into the more active T3. Healthcare providers often consider Free T4 a primary indicator of thyroid gland output.
Learn moreFree T3 (triiodothronine) is considered the most active thyroid hormone. It may play a key role in regulating metabolism, energy production, and body temperature. Healthcare providers often assess Free T3 alongside other thyroid markers for a comprehensive picture.
Learn moreTSH (Thyroid Stimulating Hormone)
ThyroidTSH, or thyroid-stimulating hormone, is produced by the pituitary gland and controls the thyroid. It is the most commonly used blood value to assess thyroid function. An abnormal TSH level can indicate an underactive thyroid (hypothyroidism) or an overactive thyroid (hyperthyroidism). Thyroid problems are common — especially in women — and can cause a wide range of symptoms, from fatigue and weight gain to palpitations and nervousness.
The thyroid affects virtually every organ in your body. The hormones it produces (T3 and T4) regulate your metabolism, heart rate, body temperature, energy level, and even your mood. When thyroid function is disrupted, the effects can be wide-ranging. Hypothyroidism (underactive) is the most common thyroid condition, affecting an estimated 5% of adults, with a clear predominance in women. It is often caused by the autoimmune condition Hashimoto's disease. Symptoms develop gradually and are therefore often recognised late. Hyperthyroidism (overactive) is less frequent but can be more serious. Graves' disease is the most common cause. Untreated, it can lead to heart rhythm disorders and bone loss. For women trying to conceive, the TSH value is particularly relevant, as suboptimal thyroid function can affect fertility and pose risks during pregnancy. A TSH below 2.5 mU/L is often used as a target in this context.
TSH Receptor Antibodies
ThyroidTSH receptor antibodies (TRAb) target the TSH receptor on thyroid cells. These antibodies are primarily associated with Graves' disease and may either stimulate or block thyroid function. Your healthcare provider can help interpret what your TRAb results mean for your thyroid health.
TRAb testing may help your healthcare provider diagnose Graves' disease, predict the likelihood of relapse after treatment, and make decisions about ongoing management. In pregnant women, TRAb levels may be monitored as these antibodies can cross the placenta and potentially affect the baby's thyroid function.
Free T4 (Thyroxine)
ThyroidFree T4 (thyroxine) is the main hormone produced by the thyroid gland. It may serve as a precursor that your body converts into the more active T3. Healthcare providers often consider Free T4 a primary indicator of thyroid gland output.
Free T4 may help your healthcare provider determine whether your thyroid gland is producing adequate hormone levels. Some experts consider it one of the most informative markers for detecting both overactive and underactive thyroid conditions early.
Free T3 (Triiodothyronine)
ThyroidFree T3 (triiodothronine) is considered the most active thyroid hormone. It may play a key role in regulating metabolism, energy production, and body temperature. Healthcare providers often assess Free T3 alongside other thyroid markers for a comprehensive picture.
Free T3 may help your healthcare provider evaluate how well your thyroid is functioning at a cellular level. Some experts suggest it can reveal conversion issues that other thyroid tests might miss, potentially offering a more complete understanding of thyroid health.
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