Cardiovascular Health
Advanced heart health panel with ApoB, Lp(a), hs-CRP, and homocysteine.
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Biomarkers Included
8 biomarkersAn advanced cardiovascular panel that goes beyond standard cholesterol testing. By including ApoB, Lipoprotein(a), hs-CRP, and Homocysteine alongside a full lipid profile, this test provides a more layered view of cardiovascular-related markers.
Why this test?
Standard lipid panels measure Total Cholesterol, HDL, LDL, and Triglycerides. While useful, these markers alone may not capture the full picture. ApoB reflects the number of potentially atherogenic particles, Lipoprotein(a) is a genetically determined risk factor that standard panels miss, hs-CRP can indicate low-grade inflammation, and Homocysteine is an amino acid whose elevated levels have been associated with cardiovascular risk. This panel combines all of these for a more detailed dataset.
Who is this test for?
This panel may be relevant for:
- Men who want to go beyond a basic cholesterol test
- Those with a family history of heart disease or stroke who want additional data points
- Men who are actively managing their cardiovascular health through diet, exercise, or supplementation and want to track relevant markers
- Anyone curious about markers like ApoB or Lp(a) that are not typically included in standard panels
What is tested?
- Total Cholesterol (mmol/l): the total amount of cholesterol in the blood.
- HDL Cholesterol (mmol/l): often referred to as "good" cholesterol; involved in reverse cholesterol transport.
- LDL Cholesterol (mmol/l): the primary carrier of cholesterol to tissues; elevated levels may be associated with increased cardiovascular risk.
- Triglycerides (mmol/l): a type of fat in the blood that can be influenced by diet, alcohol, and metabolic status.
- ApoB (g/l): Apolipoprotein B, a protein found on atherogenic lipoprotein particles. Some research suggests it may be a more precise indicator of particle number than LDL alone.
- Lipoprotein(a) (g/l): a genetically determined lipoprotein that may be associated with increased cardiovascular risk. Largely unaffected by lifestyle changes.
- hs-CRP (mg/l): high-sensitivity C-Reactive Protein, a marker that may reflect systemic low-grade inflammation.
- Homocysteine (umol/L): an amino acid; elevated levels have been associated with cardiovascular risk in some studies, and may be influenced by B-vitamin status.
What can this test tell you?
The strength of this panel lies in combining standard lipid values with advanced markers. For example, a person might have a normal LDL reading but an elevated ApoB, which could suggest a higher number of small, dense particles. A high Lp(a) value is largely genetic and cannot be changed through lifestyle, but knowing it exists allows for more informed risk discussions. Elevated hs-CRP alongside shifted lipid values may suggest an inflammatory component. Together, these markers can contribute to a more nuanced understanding of cardiovascular health when reviewed with a healthcare provider.
How is the sample collected?
A blood sample is drawn at a certified sample point (afnamepunt). There are over 750 locations across the Netherlands. After placing your order, you can select a location and time that suits your schedule. The appointment typically takes around 10 to 15 minutes.
When is this test useful?
This panel may be useful when:
- You want a more detailed cardiovascular marker profile than a standard lipid panel provides
- You have a family history of cardiovascular disease and want additional data
- Previous lipid results were borderline and you want more context
- You are tracking the impact of diet, exercise, or supplementation on cardiovascular markers
What do the results mean?
Results are presented with reference ranges for each marker. Lipid values are typically reviewed as a group; the ratios between them (such as Total Cholesterol/HDL or Triglycerides/HDL) can also be informative. ApoB and Lp(a) have their own reference ranges and are interpreted differently than standard cholesterol. hs-CRP can be influenced by recent illness or intense exercise, so context matters. A healthcare provider can help determine what the overall pattern may mean for your individual risk profile.
Preparation
Fasting for 8 to 12 hours is required for accurate lipid and triglyceride readings. Water is fine during the fasting period. Avoid intense exercise and alcohol in the 24 hours before the test, as these can temporarily affect lipid and hs-CRP values.
What happens after the results?
Results are typically available within a few business days. Your report includes values for all markers alongside reference ranges. Given the advanced nature of some markers in this panel (ApoB, Lp(a), Homocysteine), discussing the results with a healthcare provider who can contextualize them within your overall health picture is recommended.
From order to report in 4 steps
No referral needed. No waiting list. Just order and go.
Choose your blood test
Pick a testosterone check, hormone panel, or prostate screening. Or build a custom test with exactly the markers you want.
Receive your lab referral
Within 2-3 hours you'll receive an email from ZorgDomein with a barcode. Orders outside business hours are processed the next business day.
Get tested at a lab near you
Show the barcode on your phone and bring a valid ID. Done in under 15 minutes.
Receive your report from the doctor
A BIG-registered physician assesses your results and writes a personal report. On your dashboard within a few business days.
Choose your blood test
Pick a testosterone check, hormone panel, or prostate screening. Or build a custom test with exactly the markers you want.
Receive your lab referral
Within 2-3 hours you'll receive an email from ZorgDomein with a barcode. Orders outside business hours are processed the next business day.
Get tested at a lab near you
Show the barcode on your phone and bring a valid ID. Done in under 15 minutes.
Receive your report from the doctor
A BIG-registered physician assesses your results and writes a personal report. On your dashboard within a few business days.
Always a location near you
With more than 450+ certified phlebotomy points across the Netherlands.
What We Test
This panel includes 8 biomarkers, each tested at a certified laboratory using medical-grade equipment.
Apolipoprotein B (ApoB) is the main protein on LDL and other atherogenic lipoproteins. Each atherogenic particle carries exactly one ApoB molecule, making it a precise measure of the total number of particles that can contribute to plaque formation.
Learn moreTriglycerides are the most common type of fat in the body, used for energy storage. Elevated levels may be associated with increased risk of cardiovascular disease, especially when combined with other lipid abnormalities.
Learn moreHomocysteine is an amino acid produced during protein metabolism. Elevated levels may be associated with an increased risk of cardiovascular disease, cognitive decline, and other health conditions.
Learn moreLDL cholesterol, often referred to as "bad" cholesterol, is the fraction that can deposit in the walls of your blood vessels. Over time, this leads to atherosclerosis and increases the risk of heart attack or stroke. The desirable LDL level depends on your total cardiovascular risk profile — stricter targets apply for people with diabetes or a history of heart disease than for healthy individuals.
Learn moreCholesterol is a fatty substance your body needs for building cell membranes, producing hormones, and synthesising vitamin D. Your liver produces most of it; a smaller portion comes from diet. Excessively high cholesterol — particularly LDL cholesterol — increases the risk of cardiovascular disease by depositing in blood vessel walls. Total cholesterol gives a first impression, but the ratio between LDL and HDL is more clinically relevant.
Learn moreHigh-Sensitivity CRP (hs-CRP) measures very low levels of C-Reactive Protein in the blood. It is primarily used to assess cardiovascular risk by detecting low-grade chronic inflammation.
Learn moreHDL cholesterol is called "good" cholesterol because it transports cholesterol from blood vessel walls back to the liver, where it is broken down. Higher HDL therefore has a protective effect against atherosclerosis and cardiovascular disease. Unlike LDL, where a lower value is better, with HDL you want a higher value.
Learn moreLipoprotein(a), or Lp(a), is a genetically determined lipoprotein particle similar to LDL. Elevated levels are an independent risk factor for cardiovascular disease and cannot be significantly changed through lifestyle alone.
Learn moreApoB (Apolipoprotein B)
CardiovascularApolipoprotein B (ApoB) is the main protein on LDL and other atherogenic lipoproteins. Each atherogenic particle carries exactly one ApoB molecule, making it a precise measure of the total number of particles that can contribute to plaque formation.
ApoB may be a stronger predictor of cardiovascular events than LDL cholesterol because it counts all atherogenic particles, not just cholesterol content. Elevated ApoB may increase risk even when LDL appears normal. Consult your healthcare provider.
Triglycerides
CardiovascularTriglycerides are the most common type of fat in the body, used for energy storage. Elevated levels may be associated with increased risk of cardiovascular disease, especially when combined with other lipid abnormalities.
Elevated triglycerides may contribute to atherosclerosis and are a component of metabolic syndrome. They are often elevated alongside insulin resistance. Consult your healthcare provider.
Homocysteine
InflammationHomocysteine is an amino acid produced during protein metabolism. Elevated levels may be associated with an increased risk of cardiovascular disease, cognitive decline, and other health conditions.
Elevated homocysteine may be associated with cardiovascular disease, blood clots, and cognitive decline. It can also indicate B-vitamin deficiencies. Consult your healthcare provider for personalised guidance.
LDL Cholesterol
CardiovascularLDL cholesterol, often referred to as "bad" cholesterol, is the fraction that can deposit in the walls of your blood vessels. Over time, this leads to atherosclerosis and increases the risk of heart attack or stroke. The desirable LDL level depends on your total cardiovascular risk profile — stricter targets apply for people with diabetes or a history of heart disease than for healthy individuals.
LDL cholesterol is the best-established modifiable risk factor for atherosclerotic cardiovascular disease. Every 1 mmol/L reduction in LDL reduces the risk of a cardiovascular event by approximately 20–25%. This effect is independent of how the reduction is achieved — through diet, exercise, or medication. In familial hypercholesterolaemia (FH) — a hereditary condition affecting approximately 1 in 250 people — LDL is elevated from a young age, significantly increasing the risk of early cardiovascular disease. Early detection and treatment are crucial.
Total Cholesterol
CardiovascularCholesterol is a fatty substance your body needs for building cell membranes, producing hormones, and synthesising vitamin D. Your liver produces most of it; a smaller portion comes from diet. Excessively high cholesterol — particularly LDL cholesterol — increases the risk of cardiovascular disease by depositing in blood vessel walls. Total cholesterol gives a first impression, but the ratio between LDL and HDL is more clinically relevant.
Cardiovascular disease is the leading cause of death in the Netherlands. Elevated cholesterol — particularly LDL — is one of the best-established risk factors. The process of atherosclerosis progresses gradually over decades and causes no symptoms for a long time, until a heart attack or stroke occurs. The cholesterol level does not stand alone. Cardiovascular risk is determined by the interplay of cholesterol, blood pressure, age, smoking, diabetes, and family history. A cholesterol of 6.0 mmol/L in an otherwise healthy 30-year-old has a different meaning than the same value in a 60-year-old smoker with diabetes. Early detection and treatment of elevated cholesterol — through lifestyle and medication if needed — can significantly reduce the risk of cardiovascular disease.
hs-CRP (High Sensitivity CRP)
InflammationHigh-Sensitivity CRP (hs-CRP) measures very low levels of C-Reactive Protein in the blood. It is primarily used to assess cardiovascular risk by detecting low-grade chronic inflammation.
Even mildly elevated hs-CRP may be associated with increased cardiovascular risk. It provides important information beyond traditional cholesterol testing for heart disease risk assessment. Consult your healthcare provider.
HDL Cholesterol
CardiovascularHDL cholesterol is called "good" cholesterol because it transports cholesterol from blood vessel walls back to the liver, where it is broken down. Higher HDL therefore has a protective effect against atherosclerosis and cardiovascular disease. Unlike LDL, where a lower value is better, with HDL you want a higher value.
HDL has an active protective function: it removes excess cholesterol from vessel walls and transports it to the liver. This process is called reverse cholesterol transport and counteracts atherosclerosis. Low HDL is an independent risk factor for cardiovascular disease, even when LDL is normal. Low HDL is often seen with metabolic risk factors: overweight, lack of exercise, smoking, insulin resistance, and type 2 diabetes. It is therefore a marker of overall metabolic health.
Lipoprotein(a)
CardiovascularLipoprotein(a), or Lp(a), is a genetically determined lipoprotein particle similar to LDL. Elevated levels are an independent risk factor for cardiovascular disease and cannot be significantly changed through lifestyle alone.
Elevated Lp(a) is an independent and causal risk factor for cardiovascular disease. Since it is genetically determined, knowing your level helps assess inherent cardiovascular risk. Consult your healthcare provider for guidance.
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