ApoB is a protein that sits on the cholesterol particles that can build up in your artery wall. By measuring ApoB you're effectively counting the number of risk particles, not just the amount of cholesterol inside them. That's why ApoB can reflect risk more accurately than LDL alone (Sniderman, 2019).
In the Netherlands LDL is still mostly used. ApoB is tested as standard less often, while in certain situations it tells you a little more.
What exactly is ApoB?
Each harmful cholesterol particle carries one ApoB molecule. Count the ApoB and you count the number of those particles. Two men with the same LDL can have a different number of particles, and it's the number that goes with risk.
When is ApoB extra useful?
ApoB can add value with high triglycerides, overweight, diabetes or an unfavourable cholesterol profile. In those cases LDL can underestimate risk. Discuss with your GP whether ApoB adds something for you.
What do you do with the result?
A raised ApoB is a reason for a conversation about your total risk, not a diagnosis. Your GP looks at the whole picture, including blood pressure, lifestyle and family history.
Getting started
The Cardiovascular Health panel looks at markers around your cardiovascular risk. For a lipid profile there's the Lipids panel.
References
- Sniderman AD, Thanassoulis G, Glavinovic T, et al. Apolipoprotein B particles and cardiovascular disease: a narrative review. JAMA Cardiol. 2019;4(12):1287-1295. doi:10.1001/jamacardio.2019.3780.
- NHG-Standaard Cardiovascular risk management (lipids). Dutch College of General Practitioners.
- Dutch Heart Foundation (Hartstichting). Cholesterol: particles and risk.
Disclaimer
Caliberhealth works with BIG-registered doctors who assess your blood results. This article gives general information and is not a substitute for medical advice from a GP or specialist. A blood test is a tool, not a diagnosis in itself. For serious symptoms, contact your GP, or in an emergency call 112.
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